Study to Assess Safety, Tolerability and Pharmacokinetics After Single Doses of AZD1446 to Healthy Volunteers

A Phase I, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Single Ascending Dose Study to Asses the Safety, Tolerability, Pharmacokinetics of AZD1446 Including an Open Food Effect Panel in Healthy Male and Non-Fertile Female Volunteers

The primary purpose of this study is to assess the safety and tolerability of AZD1446 following single dose administration.

Inclusion Criteria:

• physical healthy volunteers
• weight between 50 to 100 kg and a body mass index (BMI) between 19 and 30 kg/m2

Exclusion Criteria:

• History of any clinically significant disease or disorder.
• History of severe allergy/hypersensitivity reactions