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| ID | Type | Description | Link |
|---|---|---|---|
| EudraCT No.: 2008-006228-76 |
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The primary purpose of this study is to assess the safety and tolerability of AZD1446 following single dose administration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AZD1446 Oral or placebo | Experimental | Single oral administration of AZD1446 or placebo |
|
| AZD1446 Oral, with or without food | Experimental | Single oral administration of AZD1446 with or without food |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AZD1446 | Drug | oral, single dose |
|
| Measure | Description | Time Frame |
|---|---|---|
| Safety and tolerability of AZD1446 by assessment of serious adverse events, ECGs, vital signs and laboratory variables | From first to last visit |
| Measure | Description | Time Frame |
|---|---|---|
| Determine the single ascending dose pharmacokinetics of AZD1446 | PK sampling taken at defined timepoints during residential period | |
| Determine the single dose of AZD1446 on food interaction | From first to last visit |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Didier Meulien, MD, PhD, MSD | AstraZeneca Södertälje | Study Director |
| Ingemar Bylesjö, MD, PhD | AstraZeneca CPU Huddinge | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research site | Huddinge | Sweden |
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| ID | Term |
|---|---|
| C578484 | 3-(5-chloro-2-furoyl)-3,7-diazabicyclo(3.3.0)octane |
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