Spironolactone and Prevention of Peritoneal Fibrosis in Peritoneal Dialysis

Role of Renin Angiotensin Blockade in Peritoneal Fibrosis in Peritoneal Dialysis Patients

This is a double blind randomized controlled study to evaluate the effect of aldactone on peritoneal fibrosis on incident peritoneal dialysis patients. The study would include a total of 40 incident peritoneal dialysis patients. Peritoneal biopsy would be made at randomization and 6 months after the intervention to evaluate the effect of renin angiotensin blockade on peritoneal fibrosis.

Inclusion Criteria:

• Age > 18
• Hospitalized for peritoneal catheter placement for peritoneal dialysis

Exclusion Criteria:

• Pregnancy
• Hiperkalemia (K> 5.5meq/l)
• Intolerance to spironolactone