Olmesartan Medoxomil Versus Losartan Potassium in Patients With Mild to Moderate Essential Hypertension

A Randomized, Double-blind, Double-dummy, Multi-center Study to Investigate the Safety and Efficacy of Olmesartan Medoxomil Compared With Losartan Potassium in Patients With Mild to Moderate Essential Hypertension

The purpose of this study is to evaluate the efficacy and safety of olmesartan medoxomil compared with losartan potassium in patients with mild to moderate essential hypertension.

Inclusion Criteria:

• mild to moderated essential hypertension (mean seated diastolic blood pressure ≥ 95 mmHg and <110 mmHg, mean seated systolic blood pressure < 180 mmHg)
• able to give written informed consent

Exclusion Criteria:

• known or suspected secondary hypertension
• history of chronic hepatic diseases
• obstructive hypertrophic cardiomyopathy/clinically significant valvular heart disease
• cardiac arrhythmia
• unstable angina pectoris
• congestive heart insufficiency (New York Heart Association classification III-IV)
• bilateral renal artery stenosis
• isolated renal artery stenosis
• post renal transplantation
• history of acute myocardial infarction/percutaneous transluminal coronary angioplasty or heart surgery within three months before enrollment
• retina bleeding/effusion
• insulin dependent diabetes mellitus
• uncontrolled non-insulin dependent diabetes mellitus