Pharmacokinetics and Pharmacodynamics of Nasally Applied Esketamine

Pharmacokinetics and Pharmacodynamics of Nasally Applied Esketamine

The purpose of this study is the determination of blood concentration and the effectiveness of esketamine after nasal application.

Inclusion Criteria:

• male
• age ≥18 years ≤ 45 years
• healthy
• non-smoking
• BMI 18-27

Exclusion Criteria:

• abuse of drugs
• known or supposed hypersensitivity and/or contraindication against ketamine or additives
• participation of another clinical study within the last 30 days
• chronic obstructed nose breathing or nasal polyps
• dug allergy
• blood donation within the last two months