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Study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery.
This study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery.
There are three groups in the study. 75 candidate of coronary artery by pass grafting surgery were assigned random allocation on the groups (25 in each group).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | No Intervention | normal procedure of CABG | |
| 2: GSE | Active Comparator | 100 mg GSE every 6h /Po, starting one day before surgery (4 doses in 24h) |
|
| 3: Vit C | Active Comparator | 25 mg/kg through pump |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GSE | Drug | grape seed extract (100 mg/6h), PO |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| LVEF | Before and after CABG |
| Measure | Description | Time Frame |
|---|---|---|
| Total Antioxidant Capacity (TAC) | Before ischemia, after ischemia, after reperfusion | |
| MDA | Before, middle and after CABG | |
| GTX |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hossein Babaei, Pharm D, PhD | Drug Applied Research Center, Tabriz Univ Med Sci | Principal Investigator |
| Naser Safaei, MD, Surgeon | Tabriz Univ Med Sci | Study Chair |
| Masood Pezaeshkian, MD | Tabriz Univ Med Sci | Principal Investigator |
| Alireza Yaghobi, MD | Tabriz Univ Med Sci | Principal Investigator |
| Ahmad Reza Jodati, MD | Tabriz Univ Med Sci | Principal Investigator |
| Hossein Babaei, Pharm D, PhD | Tabriz Univ Med Sci | Study Director |
| Rasoul Azarfarin, MD | Tabriz Univ Med Sci | Principal Investigator |
| Mohammad Ali Sheikhalizadeh, CCP | Tabriz Univ Med Sci | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular Research Center | Tabriz | East Azerbaijan Province | 51656-65811 | Iran |
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| ID | Term |
|---|---|
| D056604 | Grape Seed Extract |
| D001205 | Ascorbic Acid |
| ID | Term |
|---|---|
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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| Vit C (Ascorbic Acid) | Drug | Vit C 25 mg/ kg |
|
|
| Before ischemia, after ischemia, after reperfusion |
| SOD | Before ischemia, after ischemia, after reperfusion |
| D004364 |
| Pharmaceutical Preparations |
| D013400 | Sugar Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D006880 | Hydroxy Acids |
| D002241 | Carbohydrates |