The dimension of diagnostic procedures and therapy of chronic inflammatory bowel diseases largely depends on the degree of mucosal inflammation. Video colonoscopy is currently the gold standard in the evaluation of the mucosa in patients with Ulcerative Colitis (UC). PillCam Colon Capsule was developed by Given Imaging, Israel, as possible alternative imaging modality to evaluate mucosal changes in patients with UC. The colonic mucosa can be visualized and recorded by video while the colon capsule passes the colon.

Many patients suffering from UC ask their physician for possible alternative diagnostic imaging because they are uncomfortable with conventional colonoscopy.

The primary aim of the present study is to compare the new Pillcam Colon Capsule with standard colonoscopy with respect to assessing mucosal disease activity and localization of inflamed colonic mucosa in patients with known UC.

Inclusion Criteria:

• Patients over 18 years of age with
• known ulcerative colitis
• Indication for Standard Colonoscopy
• Informed Consent given by the patient

Exclusion Criteria:

• Patient has dysphagia
• Patient has congestive heart failure
• Patient has renal insufficiency
• Patient is known or is suspected to suffer from intestinal obstruction
• Patient has a cardiac pacemaker or other implanted electronical medical devices
• Patient is pregnant
• Patient has had prior abdominal surgery of the GI tract
• Patient has any condition, which precludes compliance with study and/or device instructions.
• Age less than 18

Patients with known ulcerative colitis