Ovarian Hyperstimulation Syndrome (OHSS) Prevention With Agonist

OHSS Prevention by GnRH-agonist Triggering of Final Oocyte Maturation and Cryoperservation of All Two-pronucleate Oocytes in Women Undergoing Stimulation for IVF With Gonadotrophins and GnRH-analogues: a Prospective, Observational, Multicentric, Clinical Cohort Study

The aim of the study is to explore the concept of GnRH-agonist triggering in combination with elective cryopreservation of all 2PN oocytes at larger scale in a pragmatic clinical setting. The question asked is: "Does GnRH-agonist triggering and cryopreservation work", in terms of efficacy and safety, when applied to a larger cohort of patients, and by a number of different centres with different clinical routines.

Inclusion Criteria:

• Indication for IVF with ICSI
• Age < 40 years
• < 4 failed previous IVF attempts with embryo transfer
• ovarian stimulation with GnRH-antagonist and gonadotrophins
• >20 follicles >11 mm in mean diameter or E2 >4500 pg/ml on the day , on which it was planned to administer hCG
• willing to participate and able to consent
• patient has not previously received GnRH-agonist as a trigger of final oocyte maturation

Exclusion Criteria:

• None