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| Name | Class |
|---|---|
| National Natural Science Foundation of China | OTHER_GOV |
| Comprehensive Strategic Cooperation Project of Guangdong Province and Chinese Academy of Science | OTHER |
| Guangzhou Science and Technology Program key projects |
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Gonadotropin releasing hormone (GnRH) agonist is sufficient for triggering final oocyte maturation in GnRH antagonist protocol and can significantly reduce incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk patients.
However, lower oocyte yield was reported in patients with lower luteinizing hormone (LH) level post trigger with single injection of GnRH agonist, which might be related to the shorter duration and lower amount of LH induced by GnRH agonist.
Our aim is to study dual trigger with GnRH agonist and human chorionic gonadotropin (hCG) for preventing OHSS and maintaining clinical outcome in high risk patients who receive controlled ovarian stimulation in GnRH antagonist protocol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.2mg triptorelin and 500 IU hCG | Experimental | Patients were triggered with 0.2mg triptorelin and 500 IU hCG |
|
| 0.2mg triptorelin and 1000 IU hCG | Experimental | Patients were triggered with 0.2mg triptorelin and 1000 IU hCG |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| triptorelin | Drug | 0.2 mg triptorelin, ih |
|
| Measure | Description | Time Frame |
|---|---|---|
| clinical pregnancy rate per transfer cycle | 1month post embryo transfer | |
| numbers of patients having OHSS | 2 weeks post trigger with dual GnRHa | |
| oocyte yield | Oocyte yield was defined as the ratio of the total number of collected oocytes to the number of follicles measuring ≥10 mm on the day of oocyte retrieval. | oocyte retrieval day (34 to 38 hours post trigger with GnRHa and hCG) |
| Oocyte maturity | Oocyte maturity was defined as the ratio of metaphase II (MII) oocytes to the number of collected oocytes in the patients undergoing with intracytoplasmic sperm injection (ICSI). | 24 hours post oocyte retrieval day |
| Measure | Description | Time Frame |
|---|---|---|
| serum luteinizing hormone level 12 hours post trigger | 12 hours post trigger | |
| serum hCG level 12 hours post trigger | 12 hours post trigger | |
| fertilization rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shi-Ling Chen, M.D., Ph.D. | Contact | +86-20-62787604 | chensl_92@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Shi-Ling Chen, M.D., Ph.D. | Nanfang Hospital, Southern Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University | Recruiting | Guangzhou | Guangdong | 510515 | China |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| D016471 | Ovarian Hyperstimulation Syndrome |
| D011085 | Polycystic Ovary Syndrome |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
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| ID | Term |
|---|---|
| D017329 | Triptorelin Pamoate |
| ID | Term |
|---|---|
| D007987 | Gonadotropin-Releasing Hormone |
| D010906 | Pituitary Hormone-Releasing Hormones |
| D007028 | Hypothalamic Hormones |
| D036361 | Peptide Hormones |
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| National Key Basic Research Development Plan of China | UNKNOWN |
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| hCG | Drug | 1000 IU hCG, im |
|
| hCG | Drug | 500IU hCG, im |
|
Fertilization rate was defined as the ratio of normal fertilized oocytes (2PNs) to the number of oocytes used for fertilization (i.e. the denominator in IVF in calculating fertilization rate is all oocytes recovered, but in ICSI it is calculated using only the number of MII oocytes). |
| 48 hours post IVF/ICSI |
| implantation rate | 1 month post embryo transfer |
| D005831 |
| Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
| D009369 | Neoplasms |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |