Safety Study to Lower the Risk of Heart Failure is Also Effective in Reducing Stiffness of the Arteries

The Effects of Nebivolol on Aortic Impedance Parameters in Type 2 Diabetics

The study is being done to see if a drug shown to lower the risk of heart failure is also effective in reducing the stiffness of the arteries.

To determine the effect of nebivolol versus metoprolol in Type 2 hypertensive diabetic patients on systolic blood pressure and diastolic blood pressure.

Inclusion Criteria:

• Established Type 2 diabetic not treated with insulin
• Stage 1 hypertensives blood pressure > 130/80 mmHg and < 160/100 mmHg
• BMI < 35
• Hemoglobin A1C < 8.5
• Must be postmenopausal or taking some form of birth control of surgically sterile

Exclusion Criteria:

• Acute myocardial infarction, unstable angina, stroke or TIA within the past year.
• Active angina in the last three months
• Diabetes requiring treatment with insulin
• Severe asthma
• Female who are pregnant, planning to be pregnant during the study period, lactating or women of childbearing potential who are not using a medically approved method of contraception
• Recent history of substance or alcohol abuse .
• Uncontrolled hypertension systolic blood pressure >160mmHg or diastolic blood pressure > 100 mmHg