Evaluation of Diet and Exercise in Patients With Non-Alcoholic Fatty Liver Disease

Prospective Histopathologic Evaluation of Diet and Exercise in Patients With Non-Alcoholic Fatty Liver Disease

Moderate exercise with a low fat and/or a moderate fat with low processed carbohydrate diet will have a greater effect on slowing disease progression and reversing hepatic steatosis and/or necro-inflammation in the liver of adult patients with NAFLD and NASH when compared to a regular healthy diet alone.

Inclusion Criteria:

• Age 18-70 yrs
• DEERS eligible (DoD beneficiary)
• All participants must plan to be in the area for at least nine months
• Liver biopsy confirmed NAFLD/NASH (NAS Score evaluating steatosis, lobular inflammation and hepatocyte ballooning) within the past 6 months

Exclusion Criteria:

• Alcohol consumption > 20 g/d or history of alcohol abuse
• Hepatitis A, B, C
• Chronic liver disease of any other etiology
• Fatty acid oxidation disorder (Inborn errors of metabolism)
• Insulin therapy regime for treatment of diabetes
• Pregnancy