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The prevalence of NAFLD is 50-70% in obese people. A decrease of calorie intake and increase of physical activity are recommended as an effective approach for the prevention and treatment of NAFLD. However, the exercise model for NAFLD intervention is understudied. In the present study we aim to compare the effect of intensive and conventional exercise interventions on NAFLD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intensive exercise | Experimental | The subjects receive an intensive exercise for 6 months and a subsequent conventional exercise for another 6 months. |
|
| Lifestyle counseling | No Intervention | Subjects receive a general lifestyle counseling for 12 months | |
| Regular exercise | Experimental | Subjects receive conventional exercise for 12 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intensive exercise | Other | Subjects conduct an aerobic exercise at 65-80% maximum oxygen consumption for 30 minutes each day, five days a week, totally for 6 months.Subsequently, moderate physical activity(3.0-6.0 MET s) at 150 min/wk for 6 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Change of intrahepatic triglyceride contents | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change of body weight | 12 months | |
| Change of waist circumference | 12 months | |
| Change of body fat |
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| Name | Affiliation | Role |
|---|---|---|
| Xiaoying Li, MD,PhD | Shanghai Jiao Tong University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Hospital Affiliated to Xiamen University | Xiamen | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27379904 | Derived | Zhang HJ, He J, Pan LL, Ma ZM, Han CK, Chen CS, Chen Z, Han HW, Chen S, Sun Q, Zhang JF, Li ZB, Yang SY, Li XJ, Li XY. Effects of Moderate and Vigorous Exercise on Nonalcoholic Fatty Liver Disease: A Randomized Clinical Trial. JAMA Intern Med. 2016 Aug 1;176(8):1074-82. doi: 10.1001/jamainternmed.2016.3202. |
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| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D001519 | Behavior |
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| Conventional exercise | Other | Subjects receive moderate physical activity(3.0-6.0 MET s) at 150 min/wk(30 min per day, five days a week) for 12 months. |
|
| 12 months |
| Change of abdominal fat | 12 montshs |
| Change of carotid intima-media thickness | 12 months |
| Change of cardiovascular risk factors (Blood pressure, lipids, glucose) | 12 months |
| Change of insulin resistance | 12 months |