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The aim of this study is to find out whether inflammation markers including cardiac markers have predictive value in evaluation of pathogenesis of sepsis in neutropenic haematological patients.
Adult AML and ASCT patients with neutropenic fever. Observation of possible progress to severe sepsis or septic shock. Blood sample collection on days 0-3 (from the beginning of neutropenic fever).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neutropenic patients | Adult AML and ASCT patients with neutropenic fever. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Severe sepsis vs. non-severe sepsis | Other | To compare these two groups |
|
| Measure | Description | Time Frame |
|---|---|---|
| This study evaluates epidemiology, microbiology and outcome of neutropenic fever and severe sepsis in haematological patients with special reference to the kinetics of inflammatory markers. | This study evaluated epidemiology, microbiology and outcome of neutropenic fever and severe sepsis in haematological patients with special reference to the kinetics of specific inflammatory markers. | Within neutropenic period after treatment |
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Inclusion Criteria:
Exclusion Criteria:
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Neutropenic patients in haematology ward having neutropenic fever with or without severe sepsis
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| Name | Affiliation | Role |
|---|---|---|
| Esa Jantunen, M.D, PhD | Kuopio University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kuopio University Hospital | Kuopio | 70211 | Finland | |||
| Kuopio University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21880642 | Derived | Vanska M, Koivula I, Hamalainen S, Pulkki K, Nousiainen T, Jantunen E, Juutilainen A. High pentraxin 3 level predicts septic shock and bacteremia at the onset of febrile neutropenia after intensive chemotherapy of hematologic patients. Haematologica. 2011 Sep;96(9):1385-9. doi: 10.3324/haematol.2011.044925. |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| Kuopio |
| Finland |
| D013568 |
| Pathological Conditions, Signs and Symptoms |