Premature Luteinization Prevention by GnRH Antagonist in Patients Undergoing IUI

GnRH Antagonist Prevention of Premature Luteinization in Patients Undergoing IUI

Premature luteinization in patients undergoing IUI can occur in up to 24% of cycles. These patients, according to recent data, have a lower pregnancy rate than controls. The possibility to avoid premature luteinization with GnRH antagonist may restore the chances of achieving a pregnancy in these women.

The purpose of this study was to investigate whether a subset of patients benefits from GnRHa administration during IUI. PL was tested for in patients who were undergoing artificial insemination procedures, and the effect of GnRHa on PR in patients who

Inclusion Criteria:

• previous failed IUI cycle with premature luteinization

Exclusion Criteria:

• 39 years or older
• not eligible for IUI (patent tubes, > 3 million capacitated spermatozoa)
• 4 previous IUI cycles