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Premature luteinization in patients undergoing IUI can occur in up to 24% of cycles. These patients, according to recent data, have a lower pregnancy rate than controls. The possibility to avoid premature luteinization with GnRH antagonist may restore the chances of achieving a pregnancy in these women.
The purpose of this study was to investigate whether a subset of patients benefits from GnRHa administration during IUI. PL was tested for in patients who were undergoing artificial insemination procedures, and the effect of GnRHa on PR in patients who
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ganirelix | Patients with premature lutenization (progesterone >1,2 ng/ml) who did not get pregnant during the first IUI underwent a second IUI. |
| |
| Control | Patients without premature lutenization (progesterone >1,2 ng/ml) underwent a only one IUI. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ganirelix | Drug | Ganirelix 0.25mg s.c every 24 h starting stimulation day 6 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pregnancy rate | 2 weeks after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| premature luteinization | at the time of intervention |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy women with patent tubes who were undergoing IUI due to infertily of unknown origin.
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| Name | Affiliation | Role |
|---|---|---|
| Juan antonio García-Velasco, MD | IVI Madrid | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IVI-Madrid | Madrid | 28023 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17936285 | Background | Kosmas IP, Tatsioni A, Kolibianakis EM, Verpoest W, Tournaye H, Van der Elst J, Devroey P. Effects and clinical significance of GnRH antagonist administration for IUI timing in FSH superovulated cycles: a meta-analysis. Fertil Steril. 2008 Aug;90(2):367-72. doi: 10.1016/j.fertnstert.2007.06.064. Epub 2007 Oct 23. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| C061018 | ganirelix |
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