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We would like to study the effect of preserving liver glycogen storage by using intravenous dextrose infusion on postoperative liver function and complications after major liver resections.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Placebo Comparator | Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output |
|
| GICP | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dextrose 10% (D10W ®) infusion | Drug | Started at 8pm the day before surgery until the procedure begins |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative liver function test | Postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Liver and muscle glycogen, TG, and protein content at beginning and end of the procedure. | Begining + end of the procedure | |
| Incidence of complications | Postoperative |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Royal Victoria Hospital | Montreal | Quebec | H3A1A1 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23339047 | Derived | Hassanain M, Metrakos P, Fisette A, Doi SA, Schricker T, Lattermann R, Carvalho G, Wykes L, Molla H, Cianflone K. Randomized clinical trial of the impact of insulin therapy on liver function in patients undergoing major liver resection. Br J Surg. 2013 Apr;100(5):610-8. doi: 10.1002/bjs.9034. Epub 2013 Jan 21. | |
| 22031518 | Derived |
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| hyperinsulinemic normoglycemic clamp | Drug | Started as the procedure begins, decreased at the end of the procedure and continued until 16 hours postoperatively |
|
| high calorie diet 35 kcal/kg | Dietary Supplement | High Calorie meals start the day before the surgery and are given 5 hours apart. The last meal is given at 7 pm the day before surgery |
|
| Intravenous normal saline (NS 0.9) | Drug | Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output |
|
| Fisette A, Hassanain M, Metrakos P, Doi SA, Salman A, Schricker T, Lattermann R, Wykes L, Nitschmann E, Smith J, Cianflone K. High-dose insulin therapy reduces postoperative liver dysfunction and complications in liver resection patients through reduced apoptosis and altered inflammation. J Clin Endocrinol Metab. 2012 Jan;97(1):217-26. doi: 10.1210/jc.2011-1598. Epub 2011 Oct 26. |
| 20375299 | Derived | Sato H, Lattermann R, Carvalho G, Sato T, Metrakos P, Hassanain M, Matsukawa T, Schricker T. Perioperative glucose and insulin administration while maintaining normoglycemia (GIN therapy) in patients undergoing major liver resection. Anesth Analg. 2010 Jun 1;110(6):1711-8. doi: 10.1213/ANE.0b013e3181d90087. Epub 2010 Apr 7. |
| ID | Term |
|---|---|
| D005947 | Glucose |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
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