Analysis of Oculo-motor Deficiencies Associated With FMR1 Gene Expression (Genetic Abnormality Predisposing to a Neurodegenerative Disease)

Analysis of Oculo-motor Deficiencies Associated With FMR1 Gene Expression (Genetic Abnormality Predisposing to a Neurodegenerative Disease)

The specific aim of this study is to compare ocular movements abnormalities between males with pre-mutation on FRM1 gene (symptomatic or asymptomatic on the motor plan and/or on the cognitive plan), males without the pre-mutation and males with multi-systematized atrophy, in order to identify the neuronal structures implicated in this pathology.

Patient will be followed at the Nantes hospital during half a day for :

• examination of ocular movements
• performing Neuro-psychological test (MATTIS)
• performing tests with scales of motricity (UPDRS, CRST, ICARS).

FOR PATIENTS WITH PREMUTATION ON FMR1 GENE (30 patients expected):

Inclusion criteria:

• Male
• > or equal to 50 years old
• Ally second or third degree with a child affected of "fragile X"
• Not living far from Nantes so that visits to the Nantes hospital can be easy
• Pre-mutation on FMR1 gene
• Signed informed consent

Exclusion criteria:

• Female
• <50 years old
• visual acuteness < 1/10
• MATTIS dementia scale <100 (normal:144)
• Occurrence, shown by MRI (Magnetic Resonance Imaging), of a pathology either ischemic vascular or hemorrhagic or tumoral

FOR PATIENTS WITHOUT PRE-MUTATION ON FMR1 GENE (10 patients expected):

Inclusion criteria:

• Male
• > or equal to 50 years old
• Ally second or third degree with a child affected of "fragile X"
• Not living far from Nantes so that visits to the Nantes hospital can be easy - Signed informed consent

Exclusion criteria:

• Female
• <50 years old
• visual acuteness < 1/10
• MATTIS dementia scale <100 (normal:144)
• Pre-mutation on FMR1 gene
• Occurrence, shown by MRI, of a pathology either ischemic vascular or hemorrhagic or tumoral

FOR PATIENTS WITH MULTI-SYSTEMATIZED ATROPHY (10 patients expected):

Inclusion criteria:

• Male
• > or equal to 50 years old
• Not living far from Nantes so that visits to the Nantes hospital can be easy
• "probable" diagnosis of multi-systematized atrophy
• Signed informed consent

Exclusion Criteria:

• Female
• <50 years old
• visual acuteness < 1/10
• MATTIS dementia scale <100 (normal:144)
• Occurrence, shown by MRI, of a pathology either ischemic vascular or hemorrhagic or tumoral