A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Pravastatin for at Least 4 Weeks.

Efficacy of WelChol as an Add-on to Pravastatin Therapy

Determine the effect of WelChol tablets on serum lipids, lipoproteins, apolipoproteins, and lipoprotein particle size in patients who were stabilized on pravastatin therapy for at least 4 weeks.

Inclusion Criteria:

• Male or female > or = to 18 years of age
• On a stable dose of pravastatin
• LDL-C > or = to 100 mg/dL and < or = 250 mg/dL
• Triglycerides < or = to 300 mg/dL
• Women are not pregnant or breast-feeding or planning to become pregnant
• Women have had a hysterectomy or tubal ligation, or who are post-menopausal or who practice an accepted method of birth control as specified in the protocol

Exclusion Criteria:

• BMI > 40 kg/m2
• History of allergic or toxic reaction to colesevelam HCL
• History of swallowing disorder
• Any serious condition that would interfere with the conduct of the study