Background: The treatment of inflammatory bowel diseases (IBD) is based mainly on 3 compounds: 1- 5 aminosalysilates . 2- immunomodulators (Azathioprines). 3- Biologic therapies (Infliximab, Adalimumab) . There are no established data in the literature whether these therapies effects sperm quality. Given that a large number of the patients are young men in the reproductive stage of their lives , It of importance to investigate these effect.

Aim: To investigate the effect of chronic treatment of any of the three therapy mentioned above, on sperm quality .

Inclusion Criteria:

• Male above the age of 18
• Capable of giving informed consent
• Diagnosed with IBD at least 3 months
• Patients that are going to start a treatment with on of the following groups: 5ASA, Azathioprines, infliximab or ADAlimumab
• Patients that are treated with therapies mentioned in article 4 for at least 3 months

Exclusion Criteria:

• Male younger than 18

Patients with inflammatory bowel disease (IBD) and healthy volunteers