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assessment of inflammatory bowel disease patients in activity and remission by abdominal ultrasound examine non-invasive and in physiological condition by measuring the colon wall thickness in diagnosis and follow up the patient also including extra intestinal features such as the splanchnic vessels,mesentery and lymph nodes . Doppler u.s can evaluate bowel wall vascularity In activity and remission . peripheral hemogram in relationship to activity inflammatory bowel disease asses anemia ,increase monocyte and decrease mean platelet volume( MPV) . also,the investigator will evaluate the outcome of different lines of treatment traditional and biologic therapy (response to treatment,times of activity and complications)
the participants will follow up the patient for 1 year in the first visit
All patients in this study will be subjected to:
Detailed history.
Careful physical examination
laboratory investigation
g-CRP (C reactive protein) f-LDH (lactate dehydrogenase)
Abdominal us(the colon wall thickness,lymph nodes,mass,other organs)
Doppler us (mesenteric vessels)
colonoscopy after 1 year of treatment follow up every 3 months by abdominal US and peripheral hemogram and last visit after 1 year colonoscopy and biopsy for assessment response to treatment
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patient on traditional therapy | Drug: steroid,5ASA , immuran for assesment the outcome of therapy in inflammatory bowel disease steroid(40- 60mg tablet),5ASA(pentasa 3-4gm tablet),azathioprin (immuran 100 mg tablet) |
| |
| patient on infliximab | drug : infliximab (5mglkg intravenous)for the first dose,the second dose after 2 weeks the third dose after 6 weeks then every 2 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Infliximab | Drug | follow up the patients who received this drugs for 1 year by abdominal ultrasound,peripheral hemogram and colonoscopy |
|
| Measure | Description | Time Frame |
|---|---|---|
| the role abdominal ultrasound in assessment inflammatory bowel disease | measure the thickness of the colon by abdominal ultrasound and doppler mesenteric vessels .more than 4ml detect activity doppler mesenteric highly vascularity in activity | 2 year |
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| Measure | Description | Time Frame |
|---|---|---|
| Assesment inflammatory bowel disease by complete blood picture | follow up haemoglobin level (less than 10 mg) indicate anemia which mean the patient uncontrolled monocyte( monocyte more than 12% of white blood cell count detect activity) Mean platelet volume less than 6 fl which decrease in activity inflammatory bowel disease | 2year |
Inclusion Criteria
Exclusion criteria
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all patients diagnosed inflammatory bowel disease (ulcerative colitis and crohns disease) at age(15 -60)
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| Name | Affiliation | Role |
|---|---|---|
| ahmed ashmawy | lecturer of internal medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hyam Fathy | Asyut | Egypt |
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| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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| ID | Term |
|---|---|
| D000069285 | Infliximab |
| D013256 | Steroids |
| ID | Term |
|---|---|
| D000911 | Antibodies, Monoclonal |
| D000906 | Antibodies |
| D007136 | Immunoglobulins |
| D007162 | Immunoproteins |
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|
| D001798 |
| Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |