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Study performed in alternative location (Beijing China)
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| Name | Class |
|---|---|
| Imperial College London | OTHER |
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The purpose of this study is to identify whether exposure to ambient levels of air pollution during normal daily activities has a functional impact on patients with coronary heart disease
Exposure to air pollution has been shown in epidemiological studies to be closely linked to cardiovascular morbidity and mortality. The exact components of air pollution that underlie the cardiovascular effects are not yet known, but combustion-derived particulate matter is suspected to be the major cause. In controlled exposure studies, we have recently demonstrated that exposure to diesel exhaust causes increased myocardial ischaemia with exercise in patients with asymptomatic coronary artery disease. The mechanism behind this effect is not yet understood, but we have shown that diesel exhaust exposure causes an acute impairment of two important and highly relevant aspects of vascular tone: vasomotor tone and endogenous fibrinolysis. In this study we propose to investigate the effects of exposure to ambient levels of air pollution on patients with stable, symptomatic angina pectoris, during their daily lives.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Patients with stable angina pectoris and documented coronary heart disease recruited in Edinburgh | ||
| 2 | Patients with stable angina pectoris and documented coronary heart disease recruited in London |
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| Measure | Description | Time Frame |
|---|---|---|
| Symptoms of angina pectoris - assessed by symptom diary and reliever medication usage | Throughout study period |
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial ischaemic burden - assessed using 12-lead continuous Holter ECG monitoring | Throughout study period | |
| Time to 1mm ST segment depression during standard BRUCE exercise stress testing | At the end of the study period |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with stable angina pectoris and documented coronary artery disease
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| Name | Affiliation | Role |
|---|---|---|
| Jeremy P Langrish, MB BCh | University of Edinburgh | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Edinburgh | Edinburgh | Midlothian | EH16 4SB | United Kingdom | ||
| Imperial College |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18057337 | Background | McCreanor J, Cullinan P, Nieuwenhuijsen MJ, Stewart-Evans J, Malliarou E, Jarup L, Harrington R, Svartengren M, Han IK, Ohman-Strickland P, Chung KF, Zhang J. Respiratory effects of exposure to diesel traffic in persons with asthma. N Engl J Med. 2007 Dec 6;357(23):2348-58. doi: 10.1056/NEJMoa071535. | |
| 17855668 | Background |
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| ID | Term |
|---|---|
| D000787 | Angina Pectoris |
| D003327 | Coronary Disease |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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Plasma samples Serum samples
| Total exercise capacity - measured using GPS tracking of activity completed | Throughout study period |
| Exercise capacity - determined by standard BRUCE exercise stress testing | Immediately after study period |
| Ambulatory blood pressure | Throughout study period |
| Biochemical evidence of myocardial ischaemia - highly sensitive troponin, ischaemically modified albumin and fatty acid binding protein | Before and after study period |
| London |
| SW3 6LY |
| United Kingdom |
| Mills NL, Tornqvist H, Gonzalez MC, Vink E, Robinson SD, Soderberg S, Boon NA, Donaldson K, Sandstrom T, Blomberg A, Newby DE. Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med. 2007 Sep 13;357(11):1075-82. doi: 10.1056/NEJMoa066314. |
| 17446340 | Background | Tornqvist H, Mills NL, Gonzalez M, Miller MR, Robinson SD, Megson IL, Macnee W, Donaldson K, Soderberg S, Newby DE, Sandstrom T, Blomberg A. Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am J Respir Crit Care Med. 2007 Aug 15;176(4):395-400. doi: 10.1164/rccm.200606-872OC. Epub 2007 Apr 19. |
| 16365212 | Background | Mills NL, Tornqvist H, Robinson SD, Gonzalez M, Darnley K, MacNee W, Boon NA, Donaldson K, Blomberg A, Sandstrom T, Newby DE. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation. 2005 Dec 20;112(25):3930-6. doi: 10.1161/CIRCULATIONAHA.105.588962. |
| D002637 |
| Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |