Adalimumab in Combination With Ciprofloxacin/Placebo Treatment of Perianal Fistulas in Crohn's

Adalimumab for the Treatment of Perianal Fistulas in Crohn's Disease More Effective Alone or Combined to Ciprofloxacin

To assess whether a combination of ciprofloxacin and adalimumab is more effective than adalimumab alone for the treatment of perianal fistulas in Crohn's disease

Dutch multicenter, randomized, double-blind study with two arms. 146 patients will be included.

Inclusion Criteria:

• proven Crohn's disease
• Single or multiple draining perianal fistulas

Exclusion Criteria:

• Abscesses
• Infliximab, cyclosporine, tacrolimus and antibiotics for Crohn's disease within past 3 months
• active viral infection
• significate cardiovascular dysfunction
• Pregnancy, Lactation
• Surgical bowel resection to be expected within 6 months
• Positive stool culture for enteric pathogens
• Total parental nutrition