The incidence of cardiovascular diseases is still high and further efforts should be done in primary prevention. The main objective is to quantify the burden of subclinical atherosclerosis using non-invasive techniques,and to study the impact of this assessment and consequent treatment in the progression of atherosclerosis and in the incidence of cardiovascular diseases.

We will perform non-invasive techniques (carotid Intima-Media Thickness, CAC score and ankle-brachial index) to individuals at intermediate cardiovascular risk.With these results, we will classify participants in: no atherosclerosis, mild, moderate and severe atherosclerosis, and therapeutic targets will be set according to pre-defined algorithms. The end-point will be the course of atherosclerosis measured by cIMT/CAC score (2 years) and the incidence of CVD at 5 years of follow-up.

Inclusion Criteria

One or more of the following:

• Familiar History of early-onset cardiovascular disease (male < 55 or female < 65).
• Type 2 Diabetes mellitus or type 1 with microalbuminuria.
• Essential High Blood Pressure.
• Chronic Kidney Disease.
• Primary hyperlipidemia.

The presence of two or more of the following:

• Current smoker.
• Physical inactivity.
• High blood pressure (recently diagnosed).
• Abdominal perimeter: > 102 cm. males; > 88 cm. females.
• Total cholesterol > 240 mg/dL.
• HDL cholesterol ≤ 40 mg/dL males, ≤ 50 mg/dL females.

Exclusion Criteria:

• Age < 40 or > 74 years old.
• Previous Cardiovascular Event.