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| ID | Type | Description | Link |
|---|---|---|---|
| IGA 2012 NT/13224 | Other Grant/Funding Number | Ministry of Health / Czech Republic Grant Agency |
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| Name | Class |
|---|---|
| Ministry of Health, Czech Republic | OTHER_GOV |
| Czech Ministry of Education | OTHER_GOV |
| University of Iowa | OTHER |
| Loyola University Chicago |
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The fundamental aim of this project is development of reliable algorithm for detection of extent and risk profile of coronary atherosclerosis based on non-invasive examinations (carotid ultrasound, examination of retinal vessel, diagnosis of endothelial dysfunction, pro-inflammatory markers including new markers of atherosclerosis and gene polymorphisms) with maximal effort on diagnosis of vulnerable plaques. The second part of the study is prediction of coronary atherosclerosis changes during high-dose lipid-lowering therapy (rosuvastatin 40 mg daily). Coronary artery impairment will be examined by up-to date technology using the fusion of angiography, intravascular ultrasound and virtual histology for 3D coronary artery reconstruction together with information about mechanical properties of arteries like a vessel shear stress. This algorithm for non-invasive assessment of coronary impairment and its changes during will be used for detection of high risk patients (in terms of acute coronary syndrome development) and of patients with low response to statin therapy. Further target is detailed assessment of atherosclerosis development and its changes during lipid-lowering therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rosuvastatin | Experimental | All patients will be using rosuvastatin 40 mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rosuvastatin | Drug | All patients will be using rosuvastatin 40 mg |
|
| Measure | Description | Time Frame |
|---|---|---|
| The prediction of plaque volume and plaque composition. | The study is looking for non-invasive predictors of plaque volume and plaque composition. The non-invasive predictors include carotid ultrasound, polymorphism in gene for heme-oxygenase 1 and retinal imaging. | The patients will be followed in the study for one year |
| Measure | Description | Time Frame |
|---|---|---|
| Prediction of changes in plaque volume and plaque composition | Prediction of changes in plaque composition and plaque volume during lipid lowering therapy based on changes of non-invasive examination. | The patients will be followed in the study for one year. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Loyola University Hospital | Active, not recruiting | Maywood | Illinois | 60153 | United States | |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23293173 | Background | Kovarnik T, Kral A, Skalicka H, Mintz GS, Kralik L, Chval M, Horak J, Skalicka L, Sonka M, Wahle A, Downe RW, Uhrova J, Benakova H, Cernohousova L, Martasek P, Belohlavek J, Aschermann M, Linhart A. The prediction of coronary artery disease based on non-invasive examinations and heme oxygenase 1 polymorphism versus virtual histology. J Invasive Cardiol. 2013 Jan;25(1):32-7. | |
| 22255863 |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 4, 2021 | |
| Reset | Apr 28, 2021 | |
| Release | Dec 19, 2021 |
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| OTHER |
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| The University of Iowa |
| Active, not recruiting |
| Iowa City |
| Iowa |
| 52242 |
| United States |
| General University Hospital | Recruiting | Prague | 12808 | Czechia |
|
| Background |
| Sonka M, Downe RW, Garvin JW, Lopez J, Kovarnik T, Wahle A. IVUS-based assessment of 3D morphology and virtual histology: prediction of atherosclerotic plaque status and changes. Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:6647-50. doi: 10.1109/IEMBS.2011.6091639. |
| 29212544 | Derived | Kovarnik T, Chen Z, Mintz GS, Wahle A, Bayerova K, Kral A, Chval M, Kopriva K, Lopez J, Sonka M, Linhart A. Plaque volume and plaque risk profile in diabetic vs. non-diabetic patients undergoing lipid-lowering therapy: a study based on 3D intravascular ultrasound and virtual histology. Cardiovasc Diabetol. 2017 Dec 7;16(1):156. doi: 10.1186/s12933-017-0637-0. |
| Reset | Jan 11, 2022 |
| Release | Jul 6, 2022 |
| Reset | Jul 26, 2022 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 4, 2021 | Apr 28, 2021 | |||
| Dec 19, 2021 | Jan 11, 2022 | |||
| Jul 6, 2022 | Jul 26, 2022 |
| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D000068718 | Rosuvastatin Calcium |
| ID | Term |
|---|---|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D005464 | Fluorobenzenes |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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