Drug Interaction Study - Effect of AZD5672 on the Pharmacokinetics of Digoxin

An Open-label Study to Assess the Effect of AZD5672 at Steady State on the Pharmacokinetics of Digoxin Following Single Dose Administration in Healthy Volunteers

The purpose of the study is to examine the effect of AZD5672 (dosed to steady state) on the pharmacokinetics of digoxin (single dose administration).

Inclusion Criteria:

• Provision of signed written informed consent.
• Females should not be of childbearing potential
• Clinically normal physical and laboratory findings as judged by the investigator, including negative drug test and negative tests of Hepatitis B surface antigen, antibodies to Hepatitis C virus and antibodies to HIV.

Exclusion Criteria:

• Any clinically significant disease or disorder which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or may influence the results of the study, or the subject's ability to participate
• Known allergy to digoxin or previous complications to digoxin therapy.
• Participation in any clinical study involving an investigational product in the 3 months prior to enrolment.