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| ID | Type | Description | Link |
|---|---|---|---|
| EudraCt nr 2008-001725-33 |
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The purpose of the study is to assess the pharmacokinetics of both AZD5672 (steady-state) and atorvastatin (single dose) when co administered in healthy volunteers
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | AZD5672 + atorvastatin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AZD5672 | Drug | 100 mg once daily, 10 days |
| |
| atorvastatin |
| Measure | Description | Time Frame |
|---|---|---|
| PK variables | Frequent sampling occasions during study periods |
| Measure | Description | Time Frame |
|---|---|---|
| Safety variables (adverse events, blood pressure, pulse, safety lab) | During the whole treatment periods |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rod Hepburn | AstraZeneca R&D, Charnwood, UK | Study Director |
| Maura Fallon | PAREXEL Clinical Pharmacology Research Unit | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | London | United Kingdom |
| ID | Term |
|---|---|
| C553747 | N-(1-(3-(3,5-difluorophenyl)-3-(4-methanesulfonylphenyl)propyl)piperidin-4-yl)-N-ethyl-2-(4-methanesulfonylphenyl)acetamide |
| D000069059 | Atorvastatin |
| ID | Term |
|---|---|
| D011758 | Pyrroles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Drug |
one single dose of 40 mg on day 10 |
|
|
| D006538 |
| Heptanoic Acids |
| D005227 | Fatty Acids |
| D008055 | Lipids |