Administration of Allogenic Red Blood Cells Loaded L-asparaginase in Cases of Relapse of Acute Lymphoblastic Leukaemia

Administration of Allogenic of Red Blood Cells Loaded L Asparaginase in Acute Lymphoblastic Leukemia Relapse.

Primary objective :

• To explore the relation between 3 doses of GRASPA and duration of asparagine depletion (< 2µmol/l)

Secondary objective :

• Pharmacokinetic / Pharmacodynamic parameters
• toxicity
• Study duration : 2 years
• Study treatment : Red blood cells loaded with L asparaginase versus native L asparaginase
• Associated treatments : COPRALL chemotherapy
• Randomization : centralised randomisation on scratching list

Inclusion Criteria:

• Subject between 1 and 55 year old
• Subject with acute lymphoblastic leukaemia or lymphoblastic lymphoma (excluded burkitt lymphoma) who have relapsed after first remission (medullary or SNC relapse)
• Or patient who still refractory to first line chemotherapy for an ALL
• Patient who gave written informed consent (2 parents for children)

Exclusion Criteria: