Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 10636 | |||
| DPG0802 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to find out whether Transference-Focused Psychotherapy (TFP) is effective in the treatment of Borderline Personality Disorder.
Borderline personality disorder represents a sever clinical condition that affects 1-2% of the community and is characterized by a pervasive instability of interpersonal relationships, self-image, and affects, as well as a marked impulsivity; up to 10% of the patients commit suicide.
Transference-Focused Psychotherapy (TFP) is one psychotherapeutic approach among five that have been manualized and evaluated in RCTs. So far, TFP has not been compared to a control condition which is a crucial step in the evaluation of the efficacy of a psychosocial intervention.
This study is an RCT that compares one year of outpatient TFP to treatment by experienced community psychotherapists for borderline personality disorder.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TFP | Active Comparator | Transference-Focused Psychotherapy |
|
| ECP | Active Comparator | treatment by experienced community psychotherapists |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transference-Focused Psychotherapy | Behavioral | Outpatient psychotherapy according to the treatment manual, sessions of 50 minutes twice per week |
|
| Measure | Description | Time Frame |
|---|---|---|
| Drop-out | Did not finish one year of treatment. | 1 year |
| Suicidality (Suicide Attempts) | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Psychosocial Functioning (Global Assessment of Functioning, GAF-Score) | 1 year | |
| Level of Personality Organization (Structured Interview for Personality Organization, STIPO) | 1 year | |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Stephan Doering, MD | University of Muenster, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of Psychoanalysis and Psychotherapy, Medical University Vienna | Vienna | State of Vienna | 1090 | Austria | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17541052 | Background | Clarkin JF, Levy KN, Lenzenweger MF, Kernberg OF. Evaluating three treatments for borderline personality disorder: a multiwave study. Am J Psychiatry. 2007 Jun;164(6):922-8. doi: 10.1176/ajp.2007.164.6.922. | |
| 17154733 | Background | Levy KN, Meehan KB, Kelly KM, Reynoso JS, Weber M, Clarkin JF, Kernberg OF. Change in attachment patterns and reflective function in a randomized control trial of transference-focused psychotherapy for borderline personality disorder. J Consult Clin Psychol. 2006 Dec;74(6):1027-1040. doi: 10.1037/0022-006X.74.6.1027. |
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| FG000 | Transferenced-Focused Psychotherapy | Transferenced-Focused Psychotherapy (TFP) |
| FG001 | Experienced Community Psychotherapists | Experienced Community Psychotherapists (ECP) |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Transferenced-Focused Psychotherapy | Transferenced-Focused Psychotherapy (TFP) |
| BG001 | Experienced Community Psychotherapists | Experienced Community Psychotherapists (ECP) |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Drop-out | Did not finish one year of treatment. | Posted | Number | participants | 1 year |
|
|
Not provided
Not provided
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Transference-Focused Psychotherapy | Transference-Focused Psychotherapy (TFP) Transference-Focused Psychotherapy: Outpatient psychotherapy according to the treatment manual, sessions of 50 minutes twice per week |
Not provided
Not provided
Not provided
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Stephan Doering | Medical University of Vienna | +43140400 | 25190 | stephan.doering@meduniwien.ac.at |
Not provided
| ID | Term |
|---|---|
| D001883 | Borderline Personality Disorder |
| ID | Term |
|---|---|
| D010554 | Personality Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| treatment by experienced community psychotherapists | Behavioral | Outpatient psychotherapy in private practices or outpatient units of psychiatric hospitals. Licensed psychotherapists with experience and special interest in the treatment of borderline patients are treating according to the method they have learned. |
|
| Number of Self-harming Acts |
| 1 year |
| Self-assessment of Psychopathology (BDI, STAI, BSI) | 1 year |
| Attachment Style and Reflective Function (Adult Attachment Interview, AAI) | 1 year |
| Borderline Symptomatology (DSM-IV Criteria) | 1 month |
| Dept. of Psychiatry, Technical University of Munich |
| Munich |
| Bavaria |
| 81675 |
| Germany |
| 18558958 | Background | Kernberg OF, Yeomans FE, Clarkin JF, Levy KN. Transference focused psychotherapy: overview and update. Int J Psychoanal. 2008 Jun;89(3):601-20. doi: 10.1111/j.1745-8315.2008.00046.x. |
| 40877786 | Derived | Schmitz-Riol S, Fuchshuber J, Herpertz J, Buchheim A, Horz-Sagstetter S, Rentrop M, Fischer-Kern M, Buchheim P, Taylor J, Tmej A, Weihs KL, Lane RD, Doering S. Emotion word repertoire in the adult attachment interview predicts a reduction of non-suicidal self-injury in the psychotherapy of borderline personality disorder. BMC Psychiatry. 2025 Aug 28;25(1):832. doi: 10.1186/s12888-025-07300-6. |
| 33884617 | Derived | Witt KG, Hetrick SE, Rajaram G, Hazell P, Taylor Salisbury TL, Townsend E, Hawton K. Psychosocial interventions for self-harm in adults. Cochrane Database Syst Rev. 2021 Apr 22;4(4):CD013668. doi: 10.1002/14651858.CD013668.pub2. |
| 32368793 | Derived | Storebo OJ, Stoffers-Winterling JM, Vollm BA, Kongerslev MT, Mattivi JT, Jorgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E. Psychological therapies for people with borderline personality disorder. Cochrane Database Syst Rev. 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2. |
| 20435966 | Derived | Doering S, Horz S, Rentrop M, Fischer-Kern M, Schuster P, Benecke C, Buchheim A, Martius P, Buchheim P. Transference-focused psychotherapy v. treatment by community psychotherapists for borderline personality disorder: randomised controlled trial. Br J Psychiatry. 2010 May;196(5):389-95. doi: 10.1192/bjp.bp.109.070177. |
| BG002 | Total | Total of all reporting groups |
| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
|
|
| Primary | Suicidality (Suicide Attempts) | Not Posted | 1 year |
| Secondary | Psychosocial Functioning (Global Assessment of Functioning, GAF-Score) | Not Posted | 1 year |
| Secondary | Level of Personality Organization (Structured Interview for Personality Organization, STIPO) | Not Posted | 1 year |
| Secondary | Number of Self-harming Acts | Not Posted | 1 year |
| Secondary | Self-assessment of Psychopathology (BDI, STAI, BSI) | Not Posted | 1 year |
| Secondary | Attachment Style and Reflective Function (Adult Attachment Interview, AAI) | Not Posted | 1 year |
| Secondary | Borderline Symptomatology (DSM-IV Criteria) | Not Posted | 1 month |
| 0 |
| 0 |
| 0 |
| 0 |
| EG001 | Treatment by Experienced Community Psychotherapists | treatment by experienced community psychotherapists (ECP) treatment by experienced community psychotherapists: Outpatient psychotherapy in private practices or outpatient units of psychiatric hospitals. Licensed psychotherapists with experience and special interest in the treatment of borderline patients are treating according to the method they have learned. | 0 | 0 | 0 | 0 |
Not provided
Not provided
Not provided