Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm

Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm Determined by Dynamic Analysis of Exhaled Breath Condensate.

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

Inclusion Criteria:

• Physician diagnosed asthma
• Age 12-75 yrs
• FEV1 > 70% predicted
• HIB response > 10 %
• No smoking last 6 mo and < 10 pack yrs
• No URI last 4 weeks
• No asthma exacerbation last 4 weks
• Able to withhold SABA > 8 hrs and LABA > 24 hrs

Exclusion Criteria:

• Other lung disease
• Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers