Using Beta Blockers to Treat Mitral Regurgitation

Beta-Blockade in Chronic Mitral Regurgitation: Moving From the Laboratory Experiment to Clinical Investigation

The purpose of this study tests whether beta-blocker will benefit asymptomatic patients with chronic primary mitral regurgitation.

The purpose of this study tests 1) whether Toprol xl, a beta-blocker will benefit asymptomatic patients with chronic primary mitral regurgitation; 2) investigate the effects of chronic mitral regurgitation on left ventricular remodeling, left ventricular function,exercise capacity and clinical symptoms.

Inclusion Criteria:

• Diagnosis of sever primary mitral regurgitation
• Normal subjects

Exclusion Criteria:

• Left ventricle ejection fraction of <55% pre and post operation
• Pregnancy or Lactation
• Secondary mitral regurgitation due to coronary artery disease, cardiomyopathy, uncontrolled hypertension, or severe aortic stenosis.