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The primary objective is to estimate surgical treatment (prosthesis or plastic) of moderate and severe ischemic mitral regurgitation combined with CABG in patients with CAD and impact on heart failure and progress of mitral regurgitation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| subgroup B1 | Active Comparator | subgroup B1 will receive CABG combined with MV repair with annuloplasty rigid ring |
|
| subgroup B2 | Active Comparator | B2 - CABG combined with MV repair with remodeling annuloplasty rigid ring and endoventricularplasty of subvalvular apparatus |
|
| subgroup A2 | Active Comparator | CABG combined with MV repair with remodeling annuloplasty rigid ring |
|
| subgroup A1 | Active Comparator | only CABG |
|
| subgroup B3 | Active Comparator | patients in subgroup B3 will be performed CABG and MV replacement with preservation of subvalvular apparatus |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CABG | Procedure | CABG |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Assess the degree of mitral regurgitation in the early and late term of the study. Identify the cause of the return of IMR. Determine the dynamics of heart failure in patients with IMR. | 3,6,12,24,36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of IMR | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
The patient did not sign the informed consent.
Aortic valve disease requiring prosthetic or aortic valve repair.
Organic lesion of valve and subvalvular structures (endocarditis and degenerative processes of the mitral valve).
а) separation of the mitral valve chords; б) rupture and perforation of the mitral valve; в) myxomatous degeneration and calcification of the mitral valve
Patients with acute coronary syndrome.
The presence of the indications for angioplasty of the coronary arteries.
Coronary artery bypasses grafting in history.
Parallel patient participation in other studies.
The organs diseases, which can be reason to death after surgery during the first 3 years.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alexander Cherniavskiy, MD, Prof. | Contact | +7 383 3322655 | amchern@mail.ru | |
| Vidadi Efendiev, MD | Contact | +7 383 3322655 | vidadiue@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Alexander Cherniavskiy, MD, PhD | State Research Institute of Circulation Patholody Novosibirsk, 630055 Russian Federation | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| State Research Institute of Circulation Patholody | Recruiting | Novosibirsk | 630055 | Russia |
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| CABG combined with MV repair with remodeling annuloplasty rigid ring | Procedure | CABG combined with MV repair with remodeling annuloplasty rigid ring |
|
| CABG combined with MV repair with remodeling annuloplasty rigid ring | Procedure | CABG combined with MV repair with remodeling annuloplasty rigid ring |
|
|
| CABG combined with MV repair with remodeling annuloplasty rigid ring and endoventricularplasty of subvalvular apparatus | Procedure | CABG combined with MV repair with remodeling annuloplasty |
|
|
| CABG and MV replacement | Procedure | coronary artery bypass grafting and mitral valve replacement |
|
|
| ID | Term |
|---|---|
| D008944 | Mitral Valve Insufficiency |
| D007511 | Ischemia |
| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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