The purpose of this study is to compare the efficacy and safety of titrated oral misoprostol solution with intravenous oxytocin for labor augmentation in women without adequate uterine contractions.

Numerous labor course necessitate augmentation when uterine contractions are inadequate. When the cervix is favorable, labor augmentation attempts are more likely to be successful. Augmentation is these women is traditionally undertaken with intravenous oxytocin and amniotomy, either alone or in combination.

In our previous trial, it has been proven that the method of titrated oral misoprostol is associated with a lower incidence of uterine hyperstimulation and a lower cesarean delivery rate than vaginal misoprostol for labor induction in patients with unfavorable cervix. Because administering Misoprostol solution is easy and cost saving, it is worth to develop this novel method in labor augmentation.

Inclusion Criteria:

• Pregnancy between 36 and 42 weeks of gestation
• Live singleton
• Cephalic presentation
• A reassuring fetal heart rate pattern
• Bishop score greater than 6
• Inadequate uterine contraction (less than or equal to 2 per 10 minutes)

Exclusion Criteria:

• Nonreassuring fetal heart rate pattern
• Parity more than five
• Uterine scar
• Suspected placental abruption with abnormal fetal heart rate
• Vaginal bleeding other than "bloody show"
• Significant maternal cardiac, renal, or hepatic disease
• hypersensitivity to oxytocin, misoprostol or prostaglandin analogues