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This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement.We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | patients in this group got 100mcg of intrathecal morphine. |
|
| 2 | Experimental | patients in this group got 200 mcg intrathecal morphine |
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| 3 | Experimental | patients in this group given 300 mcg intrathecal morphine. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intra thecal morphine | Drug | 100 mcg intrathecal morphine given once . |
|
| Measure | Description | Time Frame |
|---|---|---|
| pain | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| nausea and vomiting | 24 hours | |
| pruritus | 24 hours | |
| sedation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Patrick D Hassett, MD | Department of Anaesthesia, UCHG | Principal Investigator |
| John Laffey, MD | Department of Anaesthesia,UCHG | Study Chair |
| Brian Kinirons, MD | Dept of Anaesthesia , UCHG | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18816386 | Derived | Hassett P, Ansari B, Gnanamoorthy P, Kinirons B, Laffey JG. Determination Of The Efficacy And Side-effect Profile Of Lower Doses Of Intrathecal Morphine In Patients Undergoing Total Knee Arthroplasty. BMC Anesthesiol. 2008 Sep 24;8:5. doi: 10.1186/1471-2253-8-5. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| intra thecal morphine | Drug | 200 mcg intrathecal morphine given once |
|
|
| intra thecal morphine | Drug | 300 mcg intrathecal morphine given once |
|
|
| 24 hours |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |