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This study is planned to investigate the efficacy of combined infusion of intrathecal morphine and fentanyl in patients undergoing total knee arthroplasty.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intrathecal fentanyl | Active Comparator |
| |
| intrathecal morphine | Active Comparator |
| |
| intrathecal morphine and fentantyl | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intrathecal morphine | Drug | Intrathecal morphine 100 mcg will be injected. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain scores at 6 hour postoperatively | Postoperative pain scores will be measured using visual-analogue scale (0:no pain, 10: worst imaginable pain). | At 6 hour postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain scores at 12 and 24 hour postoperatively | Postoperative pain scores will be measured using visual-analogue scale (0:no pain, 10: worst imaginable pain). | At 12 and 24 hour postoperatively |
| Patient-controlled analgesic device requirements |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42185960 | Derived | Park SK, Lee J, Gim DY, Park J, Kim HC. Combined intrathecal fentanyl and morphine for postoperative analgesia after total knee arthroplasty: a randomised controlled trial. BMC Anesthesiol. 2026 May 25. doi: 10.1186/s12871-026-03940-7. Online ahead of print. |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Intrathecal fentanyl | Drug | Intrathecal fentanyl 25 mcg will be injected. |
|
The requirements of patient-controlled analgesic device will be measured. Morphine will be used for patient-controlled analgesic device. Total dose of morphine used at 6, 12, and 24 hour postoperatively will be measured. |
| At 6, 12, and 24 hour postoperatively |
| Number of participants with nausea | At 6, 12, and 24 hour postoperatively |
| Number of participants with vomiting | At 6, 12, and 24 hour postoperatively |
| Number of participants with pruritus | At 6, 12, and 24 hour postoperatively |
| Number of participants with respiratory depression | At 6, 12, and 24 hour postoperatively |