Patients after kidney transplantation received immunosuppression by Tacrolimus, MMF and steroids. In one half of the patients after 7 weeks MMF was reduced by half, and after 12 weeks it was stopped. For the others MMF remained at initial dose.

Inclusion Criteria:

• Patient has an end stage kidney disease and is a suitable candidate for primary renal transplantation or retransplantation
• Patient is receiving a kidney transplant, from a cadaveric or living donor between 5 and 65 years of age with compatible ABO blood type

Exclusion Criteria:

• Patient has an immunological high risk, defined as having a most recently measured PRA grade of >= 50% within the previous six months
• Patient requires ongoing dosing with a systemic immunosuppressive drug at study entry for any reason other than kidney transplantation
• Patient requires initial sequential or parallel therapy with immunosuppressive antibody preparation(s)
• Patient or donor is known to be HIV positive
• Patient with malignancy or history of malignancy, except non metastatic basal or squamous cell carcinoma of the skin that has been treated successfully
• Patient has significant, uncontrolled concomitant infections and/or severe diarrhoea, vomiting, or active peptic ulcer
• Patient is receiving a graft from a non-heart-beating donor
• Cold ischemia time of the donor kidney >= 40 hours