The patients about to undergo kidney transplantation will be randomized to one of the following two group:

Group FK506MR: FK506MR/MMF/steroid; Group Prograf® : Prograf® /MMF/steroid. The treatment period is 3 months( 12 weeks)

Inclusion Criteria:

• Written informed consent with the date of the patient must be obtained.
• Patient between 18-70 years of age receiving the primary kidney.
• Female patients must have a negative pregnancy test prior to the enrolment.
• Female patients of child bearing potential must agree to practice effective birth control during the study.

Exclusion Criteria:

• Kidney re-transplantation patients or received an organ transplantation other than a kidney.
• PRA>10% in the previous 6 months.
• Patient who need antibody induction therapy.
• Patient with significant liver disease, defined as having continuously elevated >2 times of SGPT and/or SGOT and/or total bilirubin levels during the past 28 days.
• Patient with severe infection requiring treatment, and/or severe diarrhea, vomiting, active upper gastrointestinal tract malabsorption or active peptic ulcer.
• Patient has any history of severe cardiovascular, respiratory disease; or history of malignancy.
• Patient is HIV or HBsAg positive.
• Patient is allergic to Prograf or macrolide antibiotics.