The Acute Effect of Atorvastain on Renal Function in Patients With Type II Diabetes

The Acute Effect of Atorvastatin on Renal Sodium Excretion, Glomerular Filtration Rate, Tubular Function and Vasoactive Hormones in Patients With Non-Insulin Dependent Type II Diabetes.

We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium excretion, glomerular filtration rate, tubular function and vasoactive hormones in patients with type II diabetes, not in treatment with insulin.

Inclusion Criteria:

1. Age: 40-70 yrs
2. estimated GFR between 30 and 90 ml/min
3. BMI<35
4. Fertile women had to use oral contraceptives or IUD
5. HbA1c< 10%
6. Urine-albumin<1,5 g/l

Exclusion Criteria:

1. Treatment with insulin
2. Cerobrovascular insult or other disease of the brain
3. Insufficiency of the heart or lungs
4. Liverdisease with ALAT > 200 U/L
5. hemoglobin < 7,0 mmol/l
6. Cancer
7. Alcohol abuse
8. Medical treatment with psycopharmaca or/and analgetics
9. Pregnancy and breast feeding, 10 blood donation one month before the study.