Acute Effect of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects

Acute Effect of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects

We wanted to test the acute effect of HMG-CoA reductase inhibition (atorvastatin) on renal hemodynamics, renal tubular function and vasoactive hormones on healthy subjects.

Inclusion Criteria:

• Both men and women
• Age: Between 20-50
• BMI<30

Exclusion Criteria:

• Clinical signs or history of disease of heart, lungs, kidneys or endocrine organs.
• Abnormal lab. tests( haemoglobin, pl. sodium, pl. potassium, pl.creatinine, pl.bilirubin, pl.ALAT, pl. cholesterol, blood glucose)
• Albuminuria or glucosuria
• Cancer
• Art. hypertension
• Alcohol abuse
• Medical treatment, except oral contraceptives
• Pregnancy or breast feeding
• Blood donation less than 1 month before study