Statin Therapy in the Treatment of Sepsis

Study of Statin Therapy in the Treatment of Sepsis

Simvastatin will attenutat IL-6 levels and lead to a more rapid shock reversal than placebo

Inclusion Criteria:

• Greater than 18 years old
• Hypotensive requiring vasopressors
• Suspected Infection

Exclusion Criteria:

• Pregnant
• Liver Failure (ALT or AST > 120)
• Rhabomyolysis (CPK > 3x normal)
• Comfort care measures status
• Chronic Liver Disease (Cirrhosis)
• Use of Cyclosporin, Digoxin, Statins
• Patients who are unable to take medications by mouth or NGT