Statin for Immunomudulation in Sepsis

Use of Statins in Modulation of Inflammatory Answer in Septic Patients

The purpose of this study is to determine whether atorvastatin can improve the inflammatory answer in the septic patients

Inclusion Criteria:

• clinical diagnosis of several sepsis or shock septic
• no more than twenty four hours than diagnosis

Exclusion Criteria:

• use of statins in the last thirty days
• unequivocal indication for statin treatment
• active treatment with imunosuppressors drugs
• High risk of rhabdomyolysis: multiple trauma, crush injuries, baseline creatinine kinase > three times upper limit of normal
• diagnosis of AIDS
• unable to receive enteral medications
• pregnancy
• expected survival of less than 48 hours