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| Name | Class |
|---|---|
| University of Toyama | OTHER |
| Chiba University | OTHER |
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The purpose of this study is to evaluate the efficacy and safety of Polyunsaturated Fatty Acid for the prevention of Posttraumatic Stress Disorder (PTSD) in patients with accidental injuries.
Accidental injuries, mostly motor vehicle accident, in civilian population are frequent events. For instance, nearly one-third of injured patients appear to develop trauma-related psychiatric illness and the major diagnoses are post-traumatic stress disorder (PTSD) and depressive disorder. Omega-3 Polyunsaturated Fatty Acid (Omega-3 PUFA) has some evidence of efficacy of treatment in patients with anxiety and mood disorders, but no evidence of preventing anxiety and mood disorders that occur subsequent to accidental injuries. We evaluate efficacy and safety of Omega-3 PUFA for the secondary prevention of Posttraumatic Stress Disorder (PTSD) and related psychiatric illness in patients with accidental injury.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Omega-3 Polyunsaturated Fatty Acid | Dietary Supplement | A capsule of omega-3 Polyunsaturated Fatty Acid, 300mg (including 70% docosahexaenoic acid, 7% eicosapentaenoic acid and other), 7 capsules per day in 12 week. |
| Measure | Description | Time Frame |
|---|---|---|
| Total score of Clinician-Administrated PTSD Scale (CAPS) | Three month |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of diagnosis of PTSD (including partial PTSD) | Three month, one month | |
| Total score of Montgomery Asberg Depression Rating Scale (MADRAS) | Three month, one month | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yutaka Mastuoka, M.D., Ph.D. | National Disaster Medical Center, Tachikawa, Tokyo ,Japan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Disaster Medical Center, Tachikawa, Tokyo ,Japan | Tachikawa | Tokyo | 190-0014 | Japan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20520307 | Result | Matsuoka Y, Nishi D, Yonemoto N, Hamazaki K, Hashimoto K, Hamazaki T. Omega-3 fatty acids for secondary prevention of posttraumatic stress disorder after accidental injury: an open-label pilot study. J Clin Psychopharmacol. 2010 Apr;30(2):217-9. doi: 10.1097/JCP.0b013e3181d48830. No abstract available. | |
| 21303552 | Result |
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| Incidence of depression evaluated by Mini-International Neuropsychiatric Interview (MINI) |
| Three month, one month |
| Autonomic response measured before, during and after script driven imagery and acoustic stimulation | Three month |
| Score of Impact of Event Scale revised (IES-R) | Three month, one month |
| Score of Hospital Anxiety and Depression scale (HADS) | Three month, one month |
| Score of health related Quality of Life scale, SF-36 | Three month, one month |
| Score of Conner-Davidson Resilience Scale (CD-RISC) | Three month, one month |
| Brain-derived neurotrophic factor (BDNF) in serum | Three month, one month |
| Number of days of leave taken from the time of injury | Three month |
| Buss-Perry Aggression Questionnaire (BAQ) | Three month, one month, baseline |
| Total score of Clinician-Administrated PTSD Scale (CAPS) | One month |
| DHEA: dehydroepiandrosterone | Three month, one month |
| NPY: neuropeptide Y | Three month, one month |
| IL-1 beta: interleukin 1 beta | Three month, one month |
| IL-6: interleukin 6 | Three month, one month |
| TNF alpha: tumor necrosis factor alpha | Three month, one month |
| D-serine | Three month, one month |
| L-serine | Three month, one month |
| DL-serine | Three month, one month |
| Activin | Three month, one month |
| Matsuoka Y. Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder? Biopsychosoc Med. 2011 Feb 8;5:3. doi: 10.1186/1751-0759-5-3. |
| 21720194 | Result | Matsuoka Y, Nishi D, Yonemoto N, Hamazaki K, Hamazaki T, Hashimoto K. Potential role of brain-derived neurotrophic factor in omega-3 Fatty Acid supplementation to prevent posttraumatic distress after accidental injury: an open-label pilot study. Psychother Psychosom. 2011;80(5):310-2. doi: 10.1159/000322980. Epub 2011 Jun 30. No abstract available. |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D004281 | Docosahexaenoic Acids |
| ID | Term |
|---|---|
| D015525 | Fatty Acids, Omega-3 |
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |
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