Study Of Single Doses Of PF-06291826 (Tafamidis) In Japanese And Western Subjects

An Investigator And Subject-Blind Phase 1 Study To Evaluate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of PF-06291826 (Tafamidis) After Single Oral Administration To Japanese And Western Healthy Subjects

The purpose of this study is the following:

• To evaluate the safety, tolerability, and pharmacokinetics (PK) of orally administered tafamidis in Japanese and Western healthy volunteers at single dose.
• To compare Japanese and Western PK profiles.
• Determine the PD stabilization effect of tafamidis on human transthyretin (TTR) in a validated ex vivo assay.

Inclusion Criteria:

• Healthy male or females.
• Body Mass Index (BMI) of 17.5 to 30.5 kg/m2.

Exclusion Criteria:

• Pregnant or nursing females.
• Females of childbearing potential who are unwilling or unable to use an acceptable method of contraception.