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| ID | Type | Description | Link |
|---|---|---|---|
| 1R03MH078098-01 | U.S. NIH Grant/Contract | View source | |
| MRPC 2917 | Other Grant/Funding Number | NIMH |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
| Albert Einstein College of Medicine | OTHER |
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This project will explore the relationship between catechol-O-methyltransferase (COMT) Val158/108Met genotype and response to a 12-week computerized neurocognitive rehabilitation (CRT) given to chronic schizophrenic patients.
Cognitive deficits play a crucial role in both the pathogenesis and prognosis of schizophrenia. The COMT gene is functionally expressed in neural systems considered important in a range of healthy brain functions and brain disorders, including schizophrenia. The COMT Met allele has been shown to be associated with a lower activity form of COMT, and with better performance on neurocognitive tests, while the COMT Val allele is associated with poorer executive cognition. This study will investigate the relationship of COMT polymorphism in patients with chronic schizophrenia with the response to CRT targeting visuospatial processing, attention, and cognitive flexibility using MATRICS Consensus Cognitive Battery (MCCB) developed by the NIH-MATRICS initiative.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CRT Group | Other |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive remediation therapy | Behavioral | 36 sessions of Computerized Cognitive Skills Training, 3 per week for 12 weeks. |
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| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the effect of the association of COMT Val108/158 Met genotype with the response to a computerized neurocognitive rehabilitation treatment in patients with chronic schizophrenia. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| To expand the response to a computerized neurocognitive rehabilitation treatment in patients with chronic schizophrenia to other haplotypes or identified genes. | 12 weeks | |
| To assess the differences in demographic variables (e.g. ethnicity, intellectual functioning as measured by WRAT III Reading test, and age) with response to computerized neurocognitive rehabilitation treatment in patients with chronic schizophrenia. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Pierre Lindenmayer, M.D. | Manhattan Psychiatric Center | Principal Investigator |
| Herbert Lachman, M.D. | Albert Einstein College of Medicine | Study Chair |
| Susan Mc Gurk, PhD | New Hampshire-Dartmouth Psychiatric Research Center | Study Chair |
| Anzalee Khan, PhD | Manhattan Psychiatric Center | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Manhattan Psychiatric Center | Wards Island | New York | 10035 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17123785 | Background | Woodward ND, Jayathilake K, Meltzer HY. COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia. Schizophr Res. 2007 Feb;90(1-3):86-96. doi: 10.1016/j.schres.2006.10.002. Epub 2006 Nov 22. | |
| 17383818 | Background | Bosia M, Bechi M, Marino E, Anselmetti S, Poletti S, Cocchi F, Smeraldi E, Cavallaro R. Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functional outcomes of classical rehabilitation and cognitive remediation in schizophrenia. Neurosci Lett. 2007 May 7;417(3):271-4. doi: 10.1016/j.neulet.2007.02.076. Epub 2007 Mar 2. |
| Label | URL |
|---|---|
| NIMH Press: Brain Scans Reveal How Gene May Boost Schizophrenia Risk | View source |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Oct 9, 2020 | |
| Reset | Nov 3, 2020 | |
| Release | Dec 3, 2020 | |
| Reset | Dec 28, 2020 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Oct 9, 2020 | Nov 3, 2020 | |||
| Dec 3, 2020 |
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| COMT Genotyping | Genetic | One time saliva sample is taken to genotype catechol-O-methyltransferase Val158/108Met alleles. |
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| 12 weeks |
| To assess the differences between antipsychotic treatment and response to computerized neurocognitive rehabilitation treatment in patients with chronic schizophrenia. | 12 weeks |
| Wikipedia: Catechol-O-methyl transferase | View source |
| Dec 28, 2020 |