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The purpose of this study is to test the usefulness of measuring plasma brain natriuretic peptide (BNP) for diagnosis and prognosis in very elderly dyspneic patients.
Measurement of BNP concentration is approved for use in the diagnosis of heart failure (HF) in elderly patients below 80 years of age. The value of plasma BNP assays as diagnostic tools has not been determined in very elderly populations because the plasma BNP increases with age. This large, multicenter, prospective, observational, study in 300 participants is aimed to prospectively test the usefulness of measuring plasma BNP for diagnosis of HF in dyspneic patients aged 80 and older.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Longitudinal | Prospective study : cohort of consecutive patients recruited over 2 years |
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| Measure | Description | Time Frame |
|---|---|---|
| Plasma BNP levels at T0 to test the optimal values of measuring plasma BNP for diagnosis of HF in patients older than 80 years. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma BNP levels at 3 times (T0, T48, Tend) to test the usefulness of measuring plasma BNP : 1.at T0 : in diagnosing HF using a 2-threshold up-and down-approach | 6 months | |
| 2.at T48 : in diagnosing and prognosing HF using a 2nd assay after 48 hours of treatment |
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Inclusion Criteria:
Exclusion Criteria:
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Defined population
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| Name | Affiliation | Role |
|---|---|---|
| Olivier Hanon, MD, PhD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Broca Hospital | Paris | 75013 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17066218 | Background | Komajda M, Hanon O, Aupetit JF, Benetos A, Berrut G, Emeriau JP, Friocourt P, Galinier M, De Groote P, Jondeau G, Jourdain P, Forette F. Management of heart failure in the elderly: recommendations from the French Society of Cardiology (SFC) and the French Society of Gerontology and Geriatrics (SFGG). J Nutr Health Aging. 2006 Sep-Oct;10(5):434-44. |
| Label | URL |
|---|---|
| The French Society of Cardiology (SFC) | View source |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D004194 | Disease |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Blood sample for brain natriuretic peptide measurement
| 6 months |
| 3.at Tend : in prognosing HF using a 3rd assay after the acute phase (composite criteria) | 6 months |
| the French Society of Gerontology and Geriatrics (SFGG). | View source |