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Study terminated due to insufficient enrollment
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The scope of the USE-BNP Trial is to investigate whether knowledge of BNP measurements, in conjunction with clinical assessment, in the outpatient setting can guide the management of therapy in patients with heart failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| BNP Open | Subjects treated based on clinical assessment and knowledge of BNP values |
| |
| Control | Subjects treated based on clinical assessment alone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| BNP assay (Siemens ADVIA Centaur BNP) | Device | Diagnostic test |
|
| Measure | Description | Time Frame |
|---|---|---|
| composite endpoint of all cause mortality, hospitalization due to worsening heart failure and administration of IV drug therapy for worsening heart failure. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| NYHA classifications in the two treatment groups | 12 months | |
| Quality of life assessments of two treatment groups | 12 months | |
| change in therapy based on BNP usage |
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Inclusion Criteria:
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Cardiology or internal medicine clinics
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| Name | Affiliation | Role |
|---|---|---|
| Denis C Phaneuf, MD | Centre Hospitalier de l'Université de Montréal (CHUM) Hôpital Hôtel Dieu | Principal Investigator |
| Serge Lepage, MD | Centre de recherche du Centre hospitalier universitaire de Sherbrooke | Principal Investigator |
| Boshara Zakhary, MD | Virginia Research Institute | Principal Investigator |
| Robert Dupuis, MD | Centre de santé et de services sociaux région de Thetford | Principal Investigator |
| Lee Marcus, MD | The Hudson Valley Heart Center | Principal Investigator |
| Thao Huynh, MD | McGill University Health Centre (MUHC) Montreal General Hospital | Principal Investigator |
| Nadia Giannetti, MD | McGill University Health Centre (MUHC) Royal Victoria Hospital | Principal Investigator |
| David Markham, MD | University of Texas Southwestern Medical Center | Principal Investigator |
| Paul Heidenreich | Palo Alto VA Health Care System |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Palo Alto VA Health Care System | Palo Alto | California | 94304 | United States | ||
| Bellevue Hospital |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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plasma
| hidden BNP value | Other | no intervention |
|
| 12 months |
| number of serious adverse events for the two groups | 12 months |
| Principal Investigator |
| William Little, MD | Wake Forest University Health Sciences | Principal Investigator |
| Eric Schaefer, MD | NYU Langone Health | Principal Investigator |
| New York |
| New York |
| 10016 |
| United States |
| The Hudson Valley Heart Center | Poughkeepsie | New York | 12601 | United States |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | United States |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | United States |
| Virginia Research Institute | Danville | Virginia | 24541 | United States |
| Centre Hospitalier Universitaire de Sherbrooke | Fleurimont | Quebec | J1H 5N4 | Canada |
| Centre Hospitalier de l'Université de Montréal (CHUM) Hôpital Hôtel Dieu | Montreal | Quebec | H2W 1T8 | Canada |
| McGill University Health Centre (MUHC) Royal Victoria Hospital | Montreal | Quebec | H3A 1A1 | Canada |
| McGill University Health Centre (MUHC) Montreal General Hospital | Montreal | Quebec | H3G 1A4 | Canada |
| Centre de santé et de services sociaux région de Thetford | Thetford-Mines | Quebec | G6G 2V4 | Canada |