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| ID | Type | Description | Link |
|---|---|---|---|
| D3560C00044 |
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The purpose of this study is to examine the changes in the carotid artery when subjects receive high or low doses of rosuvastatin.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rosuvastatin | Drug |
|
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in carotid wall volume as measured by MRI scan | At 40 weeks and 104 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Safety: adverse events & abnormal laboratory markers | 2 weekly for first 4 weeks then 4 weekly | |
| Other changes in the structure and composition of the carotid arterial wall as defined in the protocol. | At 40 weeks and 104 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tom Hatsukami | University of Washington, USA | Principal Investigator |
| Russell Esterline | AstraZeneca | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37565307 | Derived | Clezar CN, Flumignan CD, Cassola N, Nakano LC, Trevisani VF, Flumignan RL. Pharmacological interventions for asymptomatic carotid stenosis. Cochrane Database Syst Rev. 2023 Aug 4;8(8):CD013573. doi: 10.1002/14651858.CD013573.pub2. |
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| ID | Term |
|---|---|
| D016893 | Carotid Stenosis |
| D006937 | Hypercholesterolemia |
| ID | Term |
|---|---|
| D002340 | Carotid Artery Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D000068718 | Rosuvastatin Calcium |
| ID | Term |
|---|---|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D005464 | Fluorobenzenes |
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| D009422 | Nervous System Diseases |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D006845 |
| Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |