Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects

Randomized, Double-Blind, Multicenter, Trial to Assess the Effect of High & Low Doses of ZD4522 on Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects With Asymptomatic Carotid Stenosis After 24 Months of Dosing.

The purpose of this study is to examine the changes in the carotid artery when subjects receive high or low doses of rosuvastatin.

Inclusion Criteria:

• Fasting blood low density lipoprotein cholesterol level as defined by the protocol
• Diagnosed carotid arterial stenosis

Exclusion Criteria:

• The use of lipid lowering drugs or dietary supplements after Visit 1.
• Heavy or total occlusion of the carotid artery or recent stroke
• Uncontrolled hypertension, hypothyroidism, alcohol or drug abuse