A Study Comparing the Efficacy and Tolerability of Ziprasidone vs. Clozapine for the Treatment of Schizophrenia in Patients Who Continue to Have Symptoms on or Cannot Tolerate Other Antipsychotic Drugs

Double Blind, Double-Dummy Multicenter, Parallel Group Comparison Of The Efficacy And The Tolerability Of Ziprasidone Vs. Clozapine In Schizophrenic Patients Who Are Refractory And/Or Intolerant To Antipsychotic Therapy

The purpose of this study is to compare the efficacy and safety of ziprasidone and clozapine in schizophrenic patients who are resistant and/or intolerant to antipsychotic treatment

Inclusion Criteria:

• CGI - S ≥4
• PANSS ≥ 80
• Inpatients or outpatients

Exclusion Criteria:

• Patients with a history of myeloproliferative diseases, history of granulocytopenia, agranulocytosis due to a drug
• Diagnosis of substance dependence within previous 3 months using DSM-IV criteria
• History of seizure
• Organic mental disease, including mental retardation or epilepsy