Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain

Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain

To compare the analgesic and anti-hyperalgesic effect of Buprenorphine and Fentanyl against experimental pain in skin, muscle and bone. The study will be performed with healthy volunteers.

Inclusion Criteria:

• written informed consent
• men > 18 years

Exclusion Criteria:

• women
• known allergy against the investigated drugs
• ongoing participation in other experiments or participation in other experiments 14 days before screening
• previously pain or psychiatric conditions
• simultaneously use of pain killers
• alcohol
• previously drug-addict or member of family with drug-addicts
• chronic constipation
• ileus
• inflammatory bowel syndrome
• abdominal surgery within the last three months