Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine

Analgesic and Antihyperalgesic Effects of Morphine and Buprenorphine Following an Experimental Inflammatory Injury in Volunteers.

Tissue injury is associated with pain from the injured site (primary hyperalgesia) and pain from non-injured tissue in the vicinity of the trauma (secondary hyperalgesia). In the present study we investigate primary and secondary hyperalgesia in healthy volunteers following an experimental first degree burn injury.

The objectives are:

• to compare analgesic and anti-hyperalgesic effects of two opioids (morphine and buprenorphine).
• to investigate if these effects are related to the volunteers individual pain sensitivity

Please refer to:

Ravn P, Secher EL, Skram U, Therkildsen T, Christrup LL, Werner MU (2013) Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study. J Pain Res 6: 23-38. 10.2147/JPR.S36827 [doi];jpr-6-023 [pii].

Inclusion Criteria:

• healthy individuals
• adequate psychomotor performance to perform pain tests
• pain-sensitive or pain-nonsensitive according to prespecified criteria

Exclusion Criteria:

• known allergy to morphine or buprenorphine
• prior adverse experiences with opioids
• history of abuse
• females not taking P-pills
• skin lesions on the test-sites
• suffering from chronic pain
• medication with analgesics
• BMI > 28
• smoker