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We hypothesise that the addition of glutamine supplementation to both parenteral nutrition and enteral feeds in surgical newborn infants leads to a reduction in bacterial invasion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Dipeptiven (L-glutamine- Lalanine) |
|
| 2 | Placebo Comparator | Isonitrogenous Vaminolact |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Isonitrogenous Vaminolact | Dietary Supplement | Isonitrogenous Vaminolact |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Evidence of microbial invasion | 5 days |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Child Health, 30 Guilford Street | London | WC1N 1EH | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31502272 | Result | Bishay M, Simchowitz V, Harris K, Macdonald S, De Coppi P, Klein N, Eaton S, Pierro A; MIGS Trial Group. The Effect of Glutamine Supplementation on Microbial Invasion in Surgical Infants Requiring Parenteral Nutrition: Results of a Randomized Controlled Trial. JPEN J Parenter Enteral Nutr. 2020 Jan;44(1):80-91. doi: 10.1002/jpen.1700. Epub 2019 Sep 9. |
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| ID | Term |
|---|---|
| D006963 | Hyperphagia |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C054122 | alanylglutamine |
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| Dipeptiven (L-glutamine- Lalanine) |
| Drug |
0.6g/kg/day |
|