Molecule Removal and Ease of Use: A Comparison of Two Different Dialyzers

Urea, Phosphate and b2-Microglobulin Removal and Ease of Use: Comparing the Polyflux HD-C4 With the Polyflux 210H

The Polyflux HD-C4 (Gambro Renal Products) is a new dialyzer based on the existing Polyflux H membrane and dialyzer technology, but which achieves a performance comparable to Polyflux 210H in a significantly smaller device.

The objectives of this study are:

1. To compare and contrast small and large molecule removal by the Polyflux HD-C4 and Polyflux 210H dialyzers under conditions of routine hemodialysis; and,
2. To compare and contrast the ease of use of the Polyflux HD-C4 dialyzer with that of the Polyflux 210H under conditions of routine clinical use for hemodialysis.

Inclusion Criteria:

• Adults 18 years of age or older
• Stable hemodialysis prescription using Polyflux 210H or Polyflux 21R for at least 2 months prior to study enrollment
• Dialyzing through a native fistula or Gore-Tex graft.
• Blood access must be able to provide a blood flow rate of 400 ml/min.

Exclusion Criteria:

• Non-compliance with dialysis
• Hematocrit less than 28%
• Active Infection