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| ID | Type | Description | Link |
|---|---|---|---|
| D203 |
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| Name | Class |
|---|---|
| Axellus | INDUSTRY |
The objective of this intervention study is to examine the effect of n-3 LCPUFA on growth and body composition, intestinal health and microbiotic composition, immune function and risk markers for later diseases in 9-18 months old infants and toddlers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fish Oil | Experimental | containing n-3 LCPUFA |
|
| Sunflower oil | Placebo Comparator | containing n-6 PUFA |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fish Oil | Dietary Supplement | Daily dosage of 5 ml of fish oils from 9 months +/- 2weeks to 18 months +/- 4 weeks of age |
|
| Measure | Description | Time Frame |
|---|---|---|
| Growth | ||
| Body composition | ||
| Intestinal microbiota | ||
| Blood pressure | ||
| Plasma lipid profile | ||
| Insulin - glucose | ||
| Erythrocyte fatty acid composition | ||
| Ex vivo cytokine production | ||
| IGF-1 and IGFBP-3 | ||
| Adipokines | ||
| Plasma CRP | ||
| Plasma IgE |
| Measure | Description | Time Frame |
|---|---|---|
| Glucagon | ||
| Metagenome analysis (investigating the enzymatic capacity of the intestines through prokaryotic DNA sequencing) | ||
| Iron status (hemoglobin, ferritin) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kim F Michaelsen, Dr Med Sci | Dept. of Human Nutrition, LIFE, Univ. of Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of Human Nutrition | Copenhagen | Frederiksberg C | DK-1958 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26254087 | Derived | Lind MV, Martino D, Harslof LB, Kyjovska ZO, Kristensen M, Lauritzen L. Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants: A pilot study. Prostaglandins Leukot Essent Fatty Acids. 2015 Oct;101:1-7. doi: 10.1016/j.plefa.2015.07.003. Epub 2015 Jul 23. | |
| 23636240 |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D005395 | Fish Oils |
| D000074242 | Sunflower Oil |
| ID | Term |
|---|---|
| D009821 | Oils |
| D008055 | Lipids |
| D010938 | Plant Oils |
| D028321 | Plant Preparations |
| D001688 |
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| Sunflower Oil | Dietary Supplement | Daily dosage of 5 ml of sunflower oil from 9 months +/- 2weeks to 18 months +/- 4 weeks of age |
|
| faecal calprotectin |
| FADS1 and FADS2 genotypes |
| Allergy status |
| Harslof LB, Larsen LH, Ritz C, Hellgren LI, Michaelsen KF, Vogel U, Lauritzen L. FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants. Am J Clin Nutr. 2013 Jun;97(6):1403-10. doi: 10.3945/ajcn.113.058685. Epub 2013 May 1. |
| 21865979 | Derived | Andersen AD, Molbak L, Michaelsen KF, Lauritzen L. Molecular fingerprints of the human fecal microbiota from 9 to 18 months old and the effect of fish oil supplementation. J Pediatr Gastroenterol Nutr. 2011 Sep;53(3):303-9. doi: 10.1097/MPG.0b013e31821d298f. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| Biological Products |
| D045424 | Complex Mixtures |